celiac disease

Celiac Disease: Symptoms, Diagnosis, and Treatment

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Did you know that celiac disease affects about 1 in 100 people worldwide1? It’s an autoimmune disorder caused by gluten, a protein in wheat, barley, and some grains. When people with celiac eat gluten, their body attacks the small intestine, causing damage and preventing nutrient absorption2. It’s important to understand how to spot the symptoms, diagnose it, and treat it for those affected and their doctors.

Key Takeaways

  • Celiac disease is an autoimmune disorder caused by an abnormal immune response to gluten.
  • Symptoms can include digestive issues, anemia, osteoporosis, and neurological problems.
  • Diagnosis involves blood tests, genetic testing, and a biopsy of the small intestine.
  • The only treatment for celiac disease is a strict, lifelong gluten-free diet.
  • Vitamin and mineral supplements may be necessary to address nutrient deficiencies.

Blood tests are key in diagnosing celiac disease. They look for antibodies that show an immune reaction to gluten. Genetic tests help identify certain genes linked to the condition3. Endoscopy and capsule endoscopy check the small intestine for damage to the villi3.

Children with celiac disease tend to recover faster on a gluten-free diet than adults. Healing can take 3 to 6 months for kids and several years for adults3. Doctors might suggest supplements for severe anemia or nutritional issues, like copper, folic acid, iron, vitamin B-12, vitamin D, vitamin K, and zinc3.

Regular check-ups and blood tests are important to make sure a gluten-free diet is working right and to check nutritional levels3. For those with refractory celiac disease, treatment might include steroids or other drugs to manage inflammation3.

People with celiac disease must stick to a gluten-free diet for life to heal their small intestine and prevent more damage2. This means avoiding foods with wheat, barley, rye, and some oats, and checking labels for hidden gluten in foods, medicines, and supplements3.

What is Celiac Disease?

Celiac disease is an autoimmune disorder caused by eating gluten, a protein in wheat, barley, and some grains4. When someone with celiac eats gluten, their immune system attacks the small intestine. This damages the lining and stops nutrients from being absorbed4. It affects about 1% of people in Europe and North America4.

This disease runs in families, and having a family member with it increases your risk4. Most people with celiac have a specific gene that makes them more likely to get it4. It’s more common in people with certain genetic disorders and other autoimmune diseases4.

Women are more likely to have celiac disease than men4. It’s also more common in white people4. The damage from celiac can lead to poor nutrition and other health issues4.

“Celiac disease is an autoimmune disorder that occurs when the body’s immune system overreacts to the presence of gluten, a protein found in wheat, barley, and other grains.”

Only about 20% of people with celiac disease get the right diagnosis5. This shows how important it is to know about and test for this condition.

Statistic Value
Percentage of individuals with celiac disease who are accurately diagnosed 20%
Percentage of those diagnosed with celiac disease who develop dermatitis herpetiformis 25%
Percentage of those diagnosed with celiac disease who are women or assigned female at birth 60-70%
Chance of developing celiac disease for those with a first-degree relative with the condition 10%
Most common age ranges for celiac disease diagnosis Children: 8 months to 1 year
Adults: 40 to 60 years

In summary, celiac disease is caused by gluten and can harm the small intestine, making it hard to absorb nutrients46. It’s not common, but often not diagnosed, so knowing about it and getting tested is key546.

Symptoms of Celiac Disease

Celiac disease shows many symptoms, both in the gut and beyond7. Over half of adults with it don’t have digestive issues7. It’s key to know these symptoms to spot and treat this autoimmune condition.

Digestive Symptoms

People with celiac disease may have diarrhea, bloating, stomach pain, constipation, and nausea7. These problems are more usual in kids than adults8.

Non-Digestive Symptoms

Celiac disease can also cause symptoms outside the gut7. Adults often get anemia because they don’t absorb enough iron7. They might also have weaker bones, osteoporosis, and osteomalacia7. A rash called dermatitis herpetiformis is another sign, usually on the elbows and knees8.

Other symptoms include mouth sores, headaches, feeling tired, and joint pain7. Kids might have ADHD or seizures7. Babies might not grow well7.

Diagnosing celiac disease is hard because its symptoms can be like other illnesses7. If you have a family history of it or other autoimmune diseases, you’re more likely to get it9.

“Celiac disease is more common in people whose ancestors came from Europe and in white individuals.”9

Celiac Disease in Children

Celiac disease can greatly affect a child’s health and growth. Kids with this condition often face digestive problems like vomiting, diarrhea, a bloated belly, and constipation10. They might also have trouble growing, reach puberty late, and have neurological issues such as ADHD and seizures10.

This disease can make it hard for kids to absorb nutrients properly, which affects their growth and development10. About 1 in 133 people worldwide have celiac disease, making it quite common10. In the U.S., around 3 million people have been diagnosed with it10.

  1. Children with a family history of celiac disease have a 5 to 10 percent chance of getting it too10.
  2. Up to 22 percent of people with celiac disease have a family member who also has it10.
  3. If one identical twin gets celiac disease, the other twin has a 70 percent chance of getting it too10.

Celiac disease can start at any age, from childhood to adulthood10. Symptoms in kids include poor growth, losing weight, not reaching puberty on time, stomach problems, and feeling tired10. Doctors use blood tests, endoscopy, and biopsy to diagnose it in children10.

After being diagnosed, kids need to avoid gluten to help their intestines heal10. If not treated, celiac disease can lead to anemia, depression, poor nutrient absorption, and a higher risk of cancer10. Regular check-ups with doctors are key to make sure the child is doing well on a gluten-free diet and to catch any problems early10.

Symptom Prevalence in Children with Celiac Disease
Vomiting Common
Chronic Diarrhea Common
Bloated Belly Common
Constipation Common
Failure to Thrive Common
Short Stature Common
Delayed Puberty Common
ADHD Occasional
Seizures Occasional

“Celiac disease can have a profound impact on a child’s growth, development, and overall health. Early diagnosis and a strict gluten-free diet are essential to manage the condition and prevent long-term complications.”

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Causes and Risk Factors

Celiac disease is an autoimmune disorder caused by an abnormal immune response to gluten. Gluten is a protein in wheat, barley, and rye13. This condition comes from a mix of genes and environment13. Over the last 50 years, the number of people with undiagnosed celiac disease in the U.S. has jumped fourfold13.

Several factors increase the chance of getting celiac disease14. If a family member has it, the risk goes up, from 5% to 22% for first-degree relatives14. Most people with celiac disease have certain genes, found in many Europeans and about 10% of the world’s population14.

Autoimmune disorders and some chromosomal conditions raise the risk too15. Being pregnant, sick, or under stress can also trigger celiac disease14.

Risk Factor Prevalence
First-degree relative with celiac disease 5% to 22% chance of developing celiac disease14
Presence of HLA-DQ2 and/or HLA-DQ8 genes 96% of celiac disease patients have these genes14
Autoimmune disorders (e.g., type 1 diabetes, thyroid disease, microscopic colitis) Increased risk of developing celiac disease15
Chromosomal disorders (e.g., Down syndrome, Turner syndrome, Williams syndrome) Elevated risk of celiac disease15
Environmental triggers (e.g., pregnancy, surgery, illness, stress, viral infections) Can trigger the onset of celiac disease later in life14

Not everyone with these risk factors will get celiac disease14. About 30% of people carry the celiac genes, but only 3% get the disease14.

Causes and Risk Factors of Celiac Disease

Celiac disease is complex, influenced by genes and environment. Knowing the risk factors helps identify those at risk and manage the disease early131415.

“Celiac disease is a reaction to gluten in people with a genetic predisposition, and environmental changes may be a contributing factor to the increased risk in the current generation.”13

Diagnosis of Celiac Disease

To diagnose celiac disease, doctors use blood tests and a small intestine biopsy16. Blood tests look for certain antibodies that are high in people with celiac disease16. But, testing for celiac disease isn’t done often in the U.S. It’s usually for those with a family history or certain health issues like type 1 diabetes16.

An endoscopy with a biopsy is also done to confirm celiac disease16. This means taking a small sample from the intestine to check for damage from gluten16. It’s important to test before starting a gluten-free diet, as it can change the test results16.

Genetic Testing

Genetic testing helps in diagnosing celiac disease too17. Most people with celiac disease have certain genetic markers, HLA-DQ2 and HLA-DQ817. But, having these markers doesn’t mean you’ll get celiac disease. Many people without it also have these markers17.

Genetic testing is useful when the diagnosis is unclear or if there’s a family history of celiac disease17. But, it’s not enough on its own. You might still need blood tests and a biopsy17.

Timing of Diagnosis

When you get diagnosed with celiac disease matters17. Eating up to 3 grams of gluten daily for two to four weeks can help with blood tests17. Doctors usually prefer blood tests and biopsies for adults because they’re the most accurate17.

Diagnostic Test Usefulness
Blood Tests Check for specific antibodies associated with celiac disease
Genetic Testing Identify genetic markers like HLA-DQ2 and HLA-DQ8, but not sufficient for a diagnosis alone
Endoscopy and Biopsy Confirm damage to the small intestine lining, considered the most reliable method

In summary, diagnosing celiac disease combines blood tests, genetic tests, and a biopsy161718. Make sure to test before going gluten-free, as it can change the test results16.

Complications of Untreated Celiac Disease

Celiac disease is a serious condition that needs careful management with a gluten-free diet for life. If not treated, it can cause severe health problems19.

Malnutrition and Nutrient Deficiencies

Not treating celiac disease can lead to poor nutrient absorption. This can cause a lack of vitamins, minerals, and other important nutrients like iron, calcium, and vitamin D19. These shortages can lead to anemia, weak bones, and other health issues19.

Bone Health Complications

Celiac disease can harm bone health. The gut’s trouble absorbing calcium and minerals can cause weak bones and increase the chance of breaking them19.

Fertility and Reproductive Issues

Untreated celiac disease can make it hard for women to get pregnant and may lead to more miscarriages1920. Eating gluten-free can help improve fertility and pregnancy outcomes.

Lactose Intolerance and Other Digestive Issues

People with celiac disease may also have trouble digesting lactose, a sugar in dairy19. The disease can also cause ongoing diarrhea, stomach pain, and bloating.

Cancer Risk

Not treating celiac disease can raise the risk of certain cancers, like intestinal lymphoma and small bowel cancer1921. But, eating gluten-free can lower this risk to the average population level21.

Nervous System Disorders

Celiac disease can also affect the nervous system, causing issues like nerve damage, poor coordination, and seizures19.

It’s important to treat celiac disease and stick to a gluten-free diet to avoid these serious problems. Regular doctor visits and monitoring are key for those with celiac disease20.

Complication Description
Malnutrition Nutrient deficiencies due to malabsorption, leading to anemia, weakened bones, and other health issues.
Osteoporosis Decreased bone density and strength, increasing the risk of fractures.
Infertility Difficulties in conceiving and higher rates of miscarriage for women with untreated celiac disease.
Lactose Intolerance Inability to properly digest lactose, a sugar found in dairy products.
Cancer Increased risk of certain cancers, such as intestinal lymphoma and small bowel cancer, though the risk decreases with a gluten-free diet.
Nervous System Disorders Conditions like neuropathy, ataxia, and seizures may be associated with celiac disease.

“Celiac disease can have serious, long-term consequences if left untreated. It’s crucial to work closely with healthcare providers to manage the condition and prevent these complications from developing.”20

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celiac disease Treatment

For those with celiac disease, the key treatment is a strict, gluten-free diet22. This helps the small intestine heal and stops more damage from gluten22. By cutting out gluten in all forms, the small intestine can heal and absorb nutrients well again22.

Going gluten-free can greatly improve symptoms and behavior, especially in kids with celiac disease22. But healing the small intestine can take months to years22. Some people might be okay with small amounts of oats if they are labeled as gluten-free22.

Sticking to a gluten-free diet can be hard because gluten is in many products, like some medicines and cosmetics22. To get the right nutrition and manage celiac disease, seeing a dietitian is a good idea22.

People with celiac disease might also need extra help. This includes getting vaccines for infections and taking vitamins to fix nutrient gaps from the damaged intestine23.

Some people with celiac disease don’t get better with a gluten-free diet. They might need special tests and treatments, like steroids or immune system drugs23.

Researchers are looking into new ways to treat celiac disease24. They’re exploring things like hookworm larvae and new medicines to help people tolerate gluten better24. But these new treatments are still being tested and not yet widely used24.

“Following a gluten-free diet is the cornerstone of managing celiac disease and promoting the healing of the small intestine.”

In summary, a strict, gluten-free diet is the best way to treat celiac disease222324. It helps manage symptoms, stops more damage, and improves health and well-being222324.

Gluten-Free Diet

For people with celiac disease, eating gluten-free is key to staying healthy. Celiac disease is an autoimmune disorder caused by gluten, a protein in wheat, barley, and rye25. When someone with celiac eats gluten, their body reacts badly, damaging the small intestine and making it hard to absorb nutrients26.

It’s vital for those with celiac disease to stick to a gluten-free diet to lessen symptoms and avoid health issues26. This means avoiding all foods with wheat, barley, rye, and oats that might be contaminated25. Living gluten-free is a long-term commitment, as even a little gluten can be dangerous.

Identifying Gluten-Free Foods

Thankfully, there are more gluten-free options now25. You can find gluten-free bread, pasta, and other items in stores25. When shopping, always check labels and watch out for gluten in unexpected places like medicines and supplements.

  • Avoid products with wheat, barley, and rye25.
  • Be careful with corn and rice products that might have gluten25.
  • Oats are okay if they’re not processed with gluten27.
  • Use flours like potato, rice, soy, amaranth, quinoa, and buckwheat instead of wheat flour25.

Always read labels well, as gluten can be hidden in things like beer, candy, sauces, and soups26.

Strategies for a Gluten-Free Lifestyle

Living gluten-free takes effort and planning. Here are some tips:

  1. Keep separate kitchen items and utensils for gluten-free foods to prevent contamination27.
  2. Ask about ingredients when eating out and be careful about cross-contact27.
  3. Check if medicines and supplements have gluten in them26.
  4. Remember, gluten-free foods might not always be lower in calories25.

Even though gluten-free living might cost more27, it’s crucial for people with celiac disease to stay healthy.

gluten-free diet

“Adhering to a strict gluten-free diet is the only way to manage celiac disease and allow the small intestine to heal.” – Expert Dietitian

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Nutritional Supplements

People with celiac disease often face nutrient deficiencies because their bodies don’t absorb vitamins and minerals well28. At diagnosis, many lack calcium, vitamin B6, and magnesium28. Iron deficiency anemia is also common and might lead to the initial diagnosis28.

Healthcare providers may suggest supplements to fix these nutritional gaps28. Vitamin D is often advised since it’s hard to get enough from food, and people with celiac disease might not absorb it well28. It’s important to check the ingredients of vitamins and supplements for gluten28.

Following a gluten-free diet and inflammation in the gut can lead to low fiber intake28. This might mean taking psyllium fiber supplements28. Sometimes, a basic liquid multivitamin is recommended to help with nutrient intake if food alone isn’t enough28.

Common supplements for celiac disease include vitamin D, iron, magnesium, folate, and zinc28. The right dosage depends on the individual’s needs28. Probiotics might be used, but their effectiveness is still being studied28. Digestive enzymes like glutenase are also popular, but their benefits are not well-supported by science28. It’s important to be cautious with these supplements.

For people with celiac disease, eating a balanced diet and working with a healthcare provider is key28. This ensures they get the vitamins, minerals, and nutrients they need for good health28.

Celiac Disease in the United States

About 2 million people in the U.S. have celiac disease, which is about 1 percent of the population29. The number of people getting this disease is going up by about 7.5 percent each year29. If you have a family member with celiac disease, you’re 10 times more likely to get it too29.

Many people with celiac disease don’t get enough nutrients. Over 50 percent have low bone density, which can lead to osteoporosis29. Vitamin D is lacking in 64 percent of men and 71 percent of women with this condition29. Folate deficiency is common in people with digestive issues like celiac disease29. Iron deficiency or anemia affects 40 percent of those with celiac disease29. Vitamin B12 deficiency is found in 30 percent of people on a gluten-free diet for more than two years29.

People with celiac disease should work closely with their doctors to manage nutrient deficiencies and get the right supplements28. By keeping an eye on their nutrition and adjusting supplements as needed, they can better handle their condition and avoid health problems28.

“Proper supplementation is crucial for individuals with celiac disease, as nutrient deficiencies can have significant impacts on their overall health and well-being.”

Diagnosing and Managing Celiac Disease

Celiac disease is an autoimmune disorder that affects the small intestines30. It’s thought that about 3 million people in the U.S. have it, but 17% might be misdiagnosed or not diagnosed at all30. It’s often confused with irritable bowel syndrome (IBS), which affects different parts of the digestive system30.

The exact cause of celiac disease is still being researched, but genetics and certain triggers like pregnancy and stress might play a role30. People with the disease need to follow a strict gluten-free diet to avoid symptoms30. These symptoms can include diarrhea, constipation, and mood changes30. Even if someone with celiac disease accidentally eats gluten, they can have a bad reaction with symptoms like bloating and brain fog30.

Managing celiac disease well means sticking to a gluten-free diet and taking supplements if needed302829.

Follow-Up Care

Even after going gluten-free, seeing a healthcare provider often is key for those with celiac disease31. These visits help check how well the gluten-free diet is working. They look for any signs of problems or new symptoms31. Tests are done to see if there are any nutrient gaps31. They also watch for complications early to manage them well31.

Comprehensive Monitoring and Testing

People with celiac disease should see their doctors every year for check-ups and tests31. Blood tests look at iron, thyroid, vitamin B, copper, and zinc levels31. Antibody tests should go back to normal on a gluten-free diet; high levels might mean not sticking to the diet31. Bone density tests are done to check for bone health, usually a year after diagnosis31.

Endoscopy and biopsy are done a few years into a gluten-free diet to check for ongoing issues31. Repeat biopsies help see if villous atrophy is improving or not31.

But, many people with celiac disease don’t get the follow-up care they need after they’re diagnosed32. How well they stick to their diet, their symptoms, and their quality of life affect how often they see their doctors32. Not having regular check-ups after moving from pediatric to adult care doesn’t mean they have more problems or aren’t eating right32.

Guidelines stress the need for ongoing care to catch complications, nutrient gaps, and see if the gluten-free diet is working33. Kids with celiac disease need to see doctors every three to six months in the first year, then yearly if they’re doing well33. Teens should move to adult doctors with help from everyone involved, including patients, families, doctors, and dietitians33.

“Regular follow-up appointments are crucial for individuals with celiac disease to ensure the gluten-free diet is effective, address any lingering symptoms or nutrient deficiencies, and monitor for potential complications.”

By sticking with regular check-ups, people with celiac disease can handle their condition better, stay healthy, and lower the risk of serious problems313233.

Medications for Intestinal Inflammation

A gluten-free diet is key for celiac disease treatment. But, sometimes, more help is needed34. For severe cases or refractory celiac disease, doctors might use steroids or immunosuppressants to fight inflammation in the intestine34. These drugs are vital when a gluten-free diet alone isn’t enough.

Steroids and Immunosuppressants for Refractory Celiac Disease

Refractory celiac disease is a tough form of the condition. It happens when the small intestine doesn’t heal on a gluten-free diet34. Doctors might then use steroids or immunosuppressants to fight inflammation and help heal.

Steroids like prednisone can reduce inflammation and help the small intestine heal34. Immunosuppressants, such as azathioprine or cyclosporine, calm down the immune system’s overactive response34. These drugs might be used alone or together, based on what works best for each patient.

These strong medications are for the most severe cases of celiac disease. They can have serious side effects34. Patients on these treatments need close watch and regular check-ups to make sure they work well and to handle any side effects.

Using specific medications can help manage severe celiac disease symptoms and aid in healing34. But, these treatments are usually a last choice. The main goal is still to keep a strict gluten-free diet to control the disease34.

Lifestyle and Home Remedies

Managing celiac disease goes beyond just a gluten-free diet. Lifestyle changes and home remedies can also help. Joining support groups, educating others, and working with a dietitian are key strategies35.

Support Groups and Education

Being part of a celiac disease support group is vital. It offers a community, info, and emotional support35. These groups share gluten-free recipes and resources to help with symptoms and staying healthy35. Teaching family and friends about the disease helps them support you in social situations.

Partnering with a Dietitian

Working with a dietitian is crucial for a balanced gluten-free diet35. They guide on nutrition, check for nutrient gaps, and create meal plans tailored to your needs35. This is important since people with celiac disease often lack vitamin D and may have osteoporosis35.

Home Remedies for Symptom Management

Home remedies can ease celiac disease symptoms36. Herbs like ginger and mint help with bloating and other digestive issues36. Fish oil supplements can also reduce inflammation and improve nerve function35.

Celiac disease can be passed down through families35. With the right lifestyle, professional advice, and home remedies, managing symptoms becomes easier. This approach helps maintain health and well-being.

Home Remedy Beneficial Effects
Ginger Anti-inflammatory properties, aids in digestive upset, nausea, and gas36
Mint Sooths cramps, bloating, and aids in digestive issues36
Allspice Effective for acid reflux, indigestion, and menopausal symptoms36
Basil Useful for flatulence, stomach cramps, and indigestion36
Bay Leaves Eases upset stomach and aids in indigestion36
Black Pepper Stimulates digestive enzymes and promotes nutrient absorption36
Chamomile Offers relief in insomnia, muscle relaxation, anti-inflammatory, and digestive concerns36
Cilantro/Coriander Versatile beneficial properties for celiac disease36

“Adopting a supportive lifestyle and utilizing home remedies can greatly improve the quality of life for individuals with celiac disease.”

Using these strategies, along with a strict gluten-free diet, can help manage symptoms and improve health353637.

Conclusion

Celiac disease is a complex autoimmune disorder that needs a gluten-free diet for life. It affects about 0.5% to 1% of people, but more if you have type 1 diabetes38. Getting the right diagnosis and sticking to a gluten-free diet are key to managing it and avoiding serious health issues.

Not all places have the same rate of celiac disease. For example, Italy and Northern Spain have more cases39. Over the years, how celiac disease shows up has changed, as seen in an Italian study39. Researchers are still learning about what causes it and how it progresses.

Even though a gluten-free diet is the main treatment, some people might not get better with it alone40. It’s important to keep up with doctor visits, check for nutrient shortages, and work with health experts. This helps manage celiac disease well. By being informed and proactive, people with celiac disease can live a happy, gluten-free life.

FAQ

What is celiac disease?

Celiac disease is an autoimmune disorder caused by gluten. Gluten is found in wheat, barley, and other grains. When someone with celiac eats gluten, their body attacks the small intestine. This damages the lining and stops nutrient absorption.

What are the symptoms of celiac disease?

Symptoms include diarrhea, bloating, and stomach pain. You might also have constipation, nausea, and anemia. Other symptoms are osteoporosis, skin rashes, mouth sores, headaches, fatigue, and joint pain.

How does celiac disease affect children?

Kids with celiac often have vomiting, diarrhea, and a bloated belly. They might also have constipation, not growing well, and delayed puberty. Some may have ADHD or seizures.

What causes celiac disease?

It’s caused by an immune reaction to gluten. Being related to someone with the disease increases your risk. So does having certain conditions like type 1 diabetes or autoimmune thyroid disease.

How is celiac disease diagnosed?

Doctors use blood tests for antibodies and genetic markers. Then, an endoscopy with a small intestine biopsy confirms it. Make sure to test before starting a gluten-free diet to get accurate results.

What are the complications of untreated celiac disease?

Without treatment, it can lead to malnutrition and weak bones. You might have trouble with fertility, lactose intolerance, and an increased cancer risk. It can also cause nerve problems like seizures and numbness.

How is celiac disease treated?

The main treatment is a gluten-free diet. This helps the small intestine heal and prevents more damage.

What does a gluten-free diet involve?

It means avoiding all gluten-containing foods. This includes obvious items like bread and pasta, but also hidden sources in medicines and other products.

Do people with celiac disease need nutritional supplements?

Yes, supplements like iron, vitamin B12, and vitamin D may be needed. This is because the damaged small intestine can’t absorb nutrients properly.

What kind of follow-up care is needed for celiac disease?

Regular check-ups with your doctor are key. They help monitor your diet’s effects, check for new symptoms, and manage any nutrient shortfalls. This care also helps catch and treat complications early.

Are medications ever needed for celiac disease?

Yes, for severe cases or when the intestine doesn’t heal, doctors might prescribe steroids or immunosuppressants. These help control inflammation in the intestine.

What other lifestyle and home remedies can help with celiac disease?

Besides a gluten-free diet, join support groups for help. Educate your family and work with a dietitian for a balanced gluten-free diet.

Source Links

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